Which statement about tricyclic antidepressants is correct?

Tricyclic antidepressants (TCAs) are known to commonly cause orthostatic hypotension, which is a drop in blood pressure upon standing. This side effect occurs due to the way these medications affect neurotransmitter levels and receptor activity, particularly in the adrenergic system. As a result, patients taking TCAs may experience dizziness or lightheadedness when they stand up, increasing their risk of falls, particularly in the elderly or those with existing health conditions.

Understanding the effects of TCAs on blood pressure is crucial for healthcare professionals, especially when treating patients with additional risk factors such as cardiovascular diseases. This knowledge helps in monitoring and managing the potential side effects effectively, enhancing patient safety.

The other statements do not accurately represent TCA characteristics. For instance, TCAs are actually quite lethal in overdose situations compared to other antidepressant classes. Using them in individuals with cardiac disease does require caution due to the potential for exacerbating heart-related issues. Additionally, TCAs can have several significant drug interactions due to their effects on metabolic pathways, which is not indicative of the claim that they have no drug interactions.